What is Akynzeo 300mg/0.5mg Capsule?
Akynzeo 300mg/0.5mg Capsule is a combination antiemetic medication containing netupitant and palonosetron. Netupitant is a neurokinin-1 (NK₁) receptor antagonist, and palonosetron is a 5-HT₃ receptor antagonist. Together, they work synergistically to prevent both acute and delayed nausea and vomiting associated with chemotherapy .
What is the use of Akynzeo 300mg/0.5mg Capsule?
Akynzeo is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including highly emetogenic chemotherapy. It is used in combination with dexamethasone to enhance its effectiveness .
Benefits of Akynzeo 300mg/0.5mg Capsule
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Dual Mechanism of Action: Combines netupitant and palonosetron to block both NK₁ and 5-HT₃ receptors, providing comprehensive antiemetic protection.
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Single Dose Administration: Taken as a single capsule approximately one hour before chemotherapy, simplifying the dosing regimen.
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Extended Protection: Effective in preventing both acute and delayed nausea and vomiting, improving patient comfort during chemotherapy.
Side Effects of Akynzeo 300mg/0.5mg Capsule
Common Side Effects:
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Headache
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Fatigue
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Constipation
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Indigestion
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Skin redness (erythema)
Serious Side Effects:
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Serotonin Syndrome: Symptoms may include agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Immediate medical attention is required .
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Allergic Reactions: Signs include hives, chest pain, difficulty breathing, swelling of the face, lips, tongue, or throat. Seek emergency medical help if these occur
Directions for Use
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Dosage: Take one capsule approximately one hour before the start of chemotherapy.
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Administration: Swallow the capsule whole with or without food. Do not chew or crush.
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Additional Medications: Dexamethasone should be taken as prescribed by your healthcare provider, typically 30 minutes before chemotherapy and continued for several days as directed .
Safety Information
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Pregnancy and Breastfeeding: Akynzeo may harm an unborn baby. Discuss with your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while using this medication .
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Drug Interactions: Inform your healthcare provider of all medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions .
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Liver and Kidney Function: Use with caution in patients with liver or kidney disease. Dose adjustments may be necessary.
Product Availability
Akynzeo is available by prescription and can be obtained through authorized pharmacies. Consult your healthcare provider for more information on obtaining this medication.
1. What is Akynzeo 300mg/0.5mg Capsule?
Akynzeo is a combination medication containing netupitant and palonosetron, used to prevent nausea and vomiting caused by chemotherapy.
2. How does Akynzeo work?
It works by blocking neurokinin-1 (NK₁) and serotonin (5-HT₃) receptors in the brain, which helps control nausea and vomiting.
3. When should I take Akynzeo?
Akynzeo should be taken approximately one hour before starting chemotherapy.
4. Can Akynzeo be taken with food?
Yes, Akynzeo can be taken with or without food.
5. What are the common side effects of Akynzeo?
Common side effects include headache, fatigue, constipation, indigestion, and skin redness.
6. Are there any serious side effects I should watch for?
Serious side effects include symptoms of serotonin syndrome (such as agitation, hallucinations, fever) and allergic reactions (such as swelling or difficulty breathing). Seek immediate medical help if these occur.
7. Can I take Akynzeo if I am pregnant or breastfeeding?
Consult your doctor before using Akynzeo if you are pregnant or breastfeeding, as it may harm the baby.
8. How should I store Akynzeo?
Store at room temperature, away from moisture and heat.
9. Is Akynzeo available over the counter?
No, Akynzeo 300mg/0.5mg Capsule is a prescription medication.
10. Can Akynzeo be used for nausea caused by conditions other than chemotherapy?
Akynzeo 300mg/0.5mg Capsule is specifically approved for chemotherapy-induced nausea and vomiting; consult your doctor for other uses.
11. What should I do if I miss a dose?
Since Akynzeo is taken as a single dose before chemotherapy, contact your healthcare provider if you miss the dose.
12. Can Akynzeo interact with other medications?
Yes, inform your doctor about all medications you are taking to avoid interactions.
13. Can children use Akynzeo?
Akynzeo is generally not recommended for children; consult a healthcare provider for pediatric use.
14. How long does Akynzeo remain effective?
Akynzeo provides protection against nausea and vomiting for both acute and delayed phases, typically lasting several days post-chemotherapy.
15. Is it necessary to take other medications with Akynzeo?
Yes, Akynzeo is often prescribed with dexamethasone to improve anti-nausea effects.
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