WHAT IS CARBOPROST TROVETHAMINE INJECTION I.P.?
Carboprost Tromethamine Injection I.P. is a sterile solution containing carboprost tromethamine, a synthetic analogue of prostaglandin F2α. It is used primarily in obstetric and gynecological settings to control postpartum hemorrhage (PPH) and to induce therapeutic abortion in specific cases. The “I.P.” indicates that the formulation complies with Indian Pharmacopoeia standards for quality and safety.
What is the Use of CARBOPROST TROVETHAMINE INJECTION I.P.?
Carboprost Tromethamine Injection I.P. is used for:
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Controlling severe postpartum hemorrhage due to uterine atony (when the uterus fails to contract after childbirth).
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Terminating pregnancy in the second trimester, particularly in cases involving fetal anomalies or maternal health risks.
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As part of evacuation procedures following incomplete abortion.
Benefits of CARBOPROST TROVETHAMINE INJECTION I.P.
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✅ Rapid control of bleeding: Helps manage life-threatening postpartum hemorrhage quickly.
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✅ Effective uterotonic agent: Stimulates strong uterine contractions.
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✅ Alternative when oxytocin or ergometrine fail: Useful in resistant cases of uterine atony.
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✅ Useful for medical abortion: Can be used for termination in hospital settings under medical supervision.
Side Effects of CARBOPROST TROVETHAMINE INJECTION I.P.
Like all medications, this injection may cause side effects. Some are common and self-limiting, while others may require medical attention.
Common Side Effects:
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Nausea and vomiting
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Diarrhea
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Fever or chills
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Abdominal cramps
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Headache
Serious Side Effects (Seek immediate medical attention):
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Bronchospasm or breathing difficulty
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Hypertension or hypotension
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Allergic reactions (rash, itching, swelling)
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Chest pain or palpitations
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Uterine rupture (rare but serious)
Precautions & Warnings
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Contraindicated in patients with active cardiac, renal, pulmonary, or hepatic disease.
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Should not be used in women with known hypersensitivity to prostaglandins.
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Use only in hospital settings where resuscitation facilities are available.
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Not for routine induction of labor.
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Pregnancy Category C – used only when clearly needed in obstetric emergencies.
Storage Instructions
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Store at 2°C to 8°C (Refrigerated).
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Protect from light.
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Do not freeze.
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Keep out of reach of children
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What is CARBOPROST TROVETHAMINE INJECTION I.P. used for?
It is primarily used to control severe postpartum hemorrhage and to induce abortion during the second trimester in specific medical conditions. -
How does Carboprost Tromethamine work?
It mimics prostaglandin F2α, causing uterine contractions that help control bleeding or expel uterine contents. -
What is the usual dosage of Carboprost Tromethamine?
Typically, 250 mcg (1 mL) is injected intramuscularly, and it may be repeated every 15–90 minutes if needed, up to a maximum total dose of 2 mg. -
How is Carboprost Tromethamine Injection administered?
It is given as an intramuscular (IM) injection by a trained healthcare professional in a hospital setting. -
Can Carboprost Tromethamine be used for labor induction?
No, it is not approved for routine labor induction due to risks like uterine rupture and excessive contractions. -
What are the common side effects of Carboprost Tromethamine?
Common side effects include nausea, vomiting, diarrhea, fever, chills, and abdominal pain. -
Are there serious risks associated with Carboprost Tromethamine?
Yes. Serious reactions can include bronchospasm, hypertension, cardiac issues, and anaphylaxis. It should only be used under medical supervision. -
Can this injection be used during pregnancy?
It is used during pregnancy only when medically indicated, such as for therapeutic abortion or in emergencies like postpartum hemorrhage. -
Who should not take Carboprost Tromethamine?
It is contraindicated in patients with asthma, heart disease, liver or kidney dysfunction, and known hypersensitivity to prostaglandins. -
What precautions should be taken during administration?
Continuous monitoring is required. Emergency equipment and medications should be available in case of severe reactions. -
What should I do in case of a missed dose?
This medicine is administered in hospitals; missed doses are unlikely. The dosing schedule is controlled by medical staff. -
Can it be used along with oxytocin or other uterotonics?
It may be used after oxytocin or ergometrine fails, but combining uterotonics must be done cautiously and only under supervision. -
How should Carboprost Tromethamine be stored?
It should be stored in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. -
Is this injection safe for breastfeeding mothers?
Use during lactation should be evaluated by a doctor. While minimal data exists, it is often used postpartum under close observation. -
Is a prescription required for Carboprost Tromethamine?
Yes, it is a prescription-only medicine and should be used in hospital or emergency settings only.
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