Isoniazid Tablets IP

What is Isoniazid Tablets IP?

Isoniazid Tablets IP is a prescription medication used as a first-line treatment for tuberculosis (TB). It contains isoniazid, a potent antibacterial agent that works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria responsible for causing TB. These tablets are often used alone for latent TB infection or in combination with other medications for active TB disease.

---

What is the Use of Isoniazid Tablets IP?

Isoniazid Tablets IP is primarily used for:

• Treatment of active tuberculosis in combination with other anti-TB drugs.

• Prevention of tuberculosis in individuals who are at high risk of developing the disease (latent TB infection).

• Post-exposure prophylaxis in people who have been in close contact with TB patients.

It is a critical component of the World Health Organization’s recommended regimen for TB control.

---

Benefits of Isoniazid Tablets IP

• Effective TB Treatment: Isoniazid is one of the most effective drugs for eradicating TB bacteria.

• Prevents TB Spread: Helps prevent the spread of tuberculosis to others when used appropriately.

• Suitable for Long-Term Use: Can be used safely over a long duration under medical supervision.

• Cost-Effective: Provides a low-cost option for treating and preventing tuberculosis globally.

---

How Does Isoniazid Tablets IP Work?

Isoniazid works by inhibiting the synthesis of mycolic acids, which are essential components of the bacterial cell wall. This weakens and ultimately kills the bacteria, thereby controlling the infection.

---

Dosage and Administration

Isoniazid Tablets IP should be taken as prescribed by your doctor, usually on an empty stomach, either 1 hour before or 2 hours after a meal. The dosage may vary depending on whether it is used for active TB, latent TB, or preventive therapy.

---

Side Effects of Isoniazid Tablets IP

While Isoniazid is generally well tolerated, some people may experience side effects, including:

• Common Side Effects:

  • Nausea or vomiting

  • Loss of appetite

  • Tingling or numbness in hands and feet (peripheral neuropathy)

  • Fatigue

• Serious Side Effects:

  • Liver damage (hepatotoxicity)

  • Jaundice (yellowing of the skin or eyes)

  • Fever or rash

  • Mental/mood changes

Always consult your doctor if you experience unusual symptoms or persistent side effects.

---

Precautions and Warnings

• Avoid alcohol during treatment as it increases the risk of liver damage.

• Inform your doctor if you have liver disease, diabetes, or if you’re pregnant or breastfeeding.

• Vitamin B6 (pyridoxine) is often prescribed along with isoniazid to prevent nerve damage.

• What is Isoniazid Tablets IP used for?
  Isoniazid Tablets IP is primarily used for the treatment and prevention of tuberculosis (TB), both in its active and latent forms.

• How does Isoniazid work?
  Isoniazid works by inhibiting the synthesis of mycolic acid, a key component of the cell wall in Mycobacterium tuberculosis, ultimately killing the bacteria.

• Can Isoniazid be used alone to treat TB?
  No, for active TB, isoniazid is usually given in combination with other anti-TB drugs to prevent resistance. However, it can be used alone for latent TB infection.

• How should Isoniazid Tablets IP be taken?
  It should be taken on an empty stomach, at least 1 hour before or 2 hours after meals, unless your doctor instructs otherwise.

• What should I avoid while taking Isoniazid?
  Avoid alcohol and certain medications that may increase the risk of liver damage. Also, avoid foods rich in tyramine (like aged cheese and cured meats) as they may cause interactions.

• What are the common side effects of Isoniazid?
  Some common side effects include nausea, loss of appetite, fatigue, and tingling in the hands and feet (neuropathy).

• Can Isoniazid cause liver damage?
  Yes, one of the serious potential side effects is hepatotoxicity (liver damage). Regular liver function tests may be needed during long-term use.

• Do I need to take Vitamin B6 with Isoniazid?
  Yes, doctors often prescribe Vitamin B6 (pyridoxine) along with isoniazid to prevent nerve damage (peripheral neuropathy).

• Is Isoniazid safe during pregnancy?
  Isoniazid can be used during pregnancy if clearly needed, but always consult your doctor for proper evaluation and monitoring.

• How long do I need to take Isoniazid?
  Duration depends on the condition being treated. Latent TB treatment typically lasts 6–9 months, while active TB treatment is usually 6 months or longer, depending on the regimen.

• What happens if I miss a dose?
  Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double the dose to make up for a missed one.

• Can I stop taking Isoniazid if I feel better?
  No. Stopping early can lead to treatment failure, relapse, or drug resistance. Always complete the full course as prescribed.

• Can children take Isoniazid?
  Yes, isoniazid is commonly used in pediatric patients with TB, but dosing is based on body weight and should be supervised by a doctor.

• Is monitoring required while on Isoniazid therapy?
  Yes. Your doctor may monitor liver function, nerve health, and TB response throughout treatment.

• What should I do if I experience side effects from Isoniazid?
  Immediately contact your healthcare provider if you notice signs of liver issues (e.g., yellowing of the skin or eyes), rash, fatigue, or numbness in the limbs.